NOUVEAUX COMPOSES D'ADDITION D'UN DERIVE DE DIPEPTIDE ET D'UN DERIVE D'AMINO-ACIDE, ET LEUR PROCEDE DE PREPARATION ET DE DECOMPOSITION

• Main Author: YOSHIKAZU ISOWA, MUNEKI OHMORI, KAORU MORI, TETSUYA ICHIKAWA, YUJI NONAK KEIICHI KIHARA, KIYOTAKA OYAMA, HEIJIRO SATOH ET SHIGEAKI NISHIMURA
• Format: Patent
• Language: French
• Published: 25.08.1978
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

a. Nouveaux composés d'addition d'un dérivé de dipeptide et d'un dérivé d'amino-acide, et leur procédé de préparation et de décomposition b. Ces composés d'addition répondent à la formule : Addition compounds have the formula (I) wherein R1 represents an aliphatic oxycarbonyl group, benzyloxycarbonyl group which can have nuclear substituents or benzoyl, aromatic sulfonyl or aromatic sulfinyl group; R2 represents methyl, isopropyl, isobutyl, isoamyl or benzyl group; R3 represents a lower alkoxyl, benzyloxy or benzhydryloxy group and n represents 1 or 2. The addition compounds are produced by reacting an N-substituted monoaminodicarboxylic acid having the formula (IV) with an amino carboxlic acid ester having the formula (V) in an aqueous medium in the presence of a protease and reacting the resulting dipeptide ester with the amino carboxylic acid ester and separating the addition compound. The addition compounds can be decomposed into the constituent dipeptide esters and amino acid esters by the action of an acid.