Per-fluoroalkyl oxo-alkane prepn. - from per-fluoro-iodo-alkane and enamine cpds. in absence of irradiation or initiator

• Main Author: DANIELE CANTACUZENE ET CLAUDE WAKSELMAN
• Format: Patent
• Language: English; French
• Published: 06.01.1978
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

1-Perfluoroalkyl-2-oxoalkanes of formla (Ie are prepd. by reaction of a perfluoro-iodoalkane RFI with an enamine of formula (II), in absence of irradiation and/or initiator, in an inert solvent, then hydrolysising the intermediate product with acid. In (I) and (II) RF is CnH2n+1; n is 2-20; R'-2 are H, alkyl cycloalkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, alkenyl, aryl or NO2; R3 is H, alkyl, cycloalkyl, aryl, alkoxy, alkylthio or the gp. R4-5 are each alkyl; or R4+R5 and the attached N atom form a 5- or 6-membered satd. heterocyclic ring opt. contg. O; or R' and R3 together form a cycloalkyl, a steroid-like or isoprenoid polycyclic ring system r an opt. substd. satd. heterocyclic ring contg. O, S or N; (R') and (R')5 are as R4 and R5. L'addition a pour objet un procédé du type décrit au brevet principal. La réaction de l'énamine avec un perfluoroiodoalcane peut être effectuée sans irradiation et/ou initiateur, avantageusement en présence d'une amine. Les composés obtenus peuvent être utilisés pour la préparation de composés éthyléniques.