Prepn. of dibenzo-oxazepine - by iron reduction of (2)-O-nitro phenoxy benzaldehyde

Prepn. of dibenzo b,f oxazepine-1,4 of formula (I) comprises reducing 2-(2'-nitrophenoxy)-benzaldehyde with Fe powder in the presence of sulphuric acid in a reaction medium comprising a mixt. of a 1-6C alkanol and water, followed by isolation of the prod. The process gives the prod. of satisfac...

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Bibliographic Details
Main Author ANDRE TAMBUTE
Format Patent
LanguageEnglish
French
Published 16.12.1977
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Prepn. of dibenzo b,f oxazepine-1,4 of formula (I) comprises reducing 2-(2'-nitrophenoxy)-benzaldehyde with Fe powder in the presence of sulphuric acid in a reaction medium comprising a mixt. of a 1-6C alkanol and water, followed by isolation of the prod. The process gives the prod. of satisfactory quality in good yield (=80%) which comprises favourably with the known process by cyclisation of o-formylamino-diphenylether which is laborious, and gives low and variable yields.
Bibliography:Application Number: FR19760014880