Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia

Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid having 1-5 carbon atoms, wherein the carbon chain may further contain 1-4 hydroxyl, 1-3 oxo, or one or sever...

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Main Authors KORTESUO,PIRJO, OERN,GUNILLA, KIESVAARA,JUHA, KANANEN,MIKKO, SALMIA,JUKKA, AF URSIN,KAIJA, NISKANEN,HEIKKI
Format Patent
LanguageFinnish
Swedish
Published 18.06.2000
Edition7
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Summary:Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid having 1-5 carbon atoms, wherein the carbon chain may further contain 1-4 hydroxyl, 1-3 oxo, or one or several halogen substituents, or a corresponding anion thereof, or methanesulfonic acid or its corresponding anion, in molar excess with respect to the triphenylethylene antiestrogen, optionally together with an organic water miscible co-solvent such as polyethylene glycol (PEG), propylene glycol, ethanol or isopropanol.
Bibliography:Application Number: FI19980002733