Indolijohdannaiset 5-HT1-tyyppisinä agonisteina

PCT No. PCT/EP95/03884 Sec. 371 Date Apr. 3, 1997 Sec. 102(e) Date Apr. 3, 1997 PCT Filed Sep. 29, 1995 PCT Pub. No. WO96/11195 PCT Pub. Date Apr. 18, 1996Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either enti...

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Bibliographic Details
Main Author BROWN, ALAN DANIEL
Format Patent
LanguageFinnish
Swedish
Published 10.04.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/EP95/03884 Sec. 371 Date Apr. 3, 1997 Sec. 102(e) Date Apr. 3, 1997 PCT Filed Sep. 29, 1995 PCT Pub. No. WO96/11195 PCT Pub. Date Apr. 18, 1996Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either entity, wherein R1 is (a) R2 is R3R4C(OH)A; V is C=O or CH2; W is O or NR5; R3 and R4 are each independently selected from H and C1-C4 alkyl; or, together with the carbon atom to which they are attached, form a 4- or 5-membered carbocyclic ring; R5 is H, benzyl, C1-C5 alkanoyl or SO2(C1-C4)alkyl; A is C2-C3 alkylene; m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. (I) (a)
Bibliography:Application Number: FI19970001492