Uusia piperatsiinijohdoksia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä koostumuksia

PCT No. PCT/KR96/00005 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Jan. 10, 1996 PCT Pub. No. WO90/21648 PCT Pub. Date Jul. 18, 1996The present invention relates to novel compound of the general formula(I) and acid addition salt thereof. (I) wherein R1 and R2 are independent...

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Main Authors CHO, EUI-HWAN, KIM, BYUNGUL, CHUNG, SUN-GAN, KIM, JOONG-YOUNG, KWON, HO-SEOK, LEE, SUN-HWAN, KANG, DONG-WOOK, KONG, JAE-MYEONG, LEE, JAE-EUNG
Format Patent
LanguageFinnish
Swedish
Published 10.09.1996
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/KR96/00005 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Jan. 10, 1996 PCT Pub. No. WO90/21648 PCT Pub. Date Jul. 18, 1996The present invention relates to novel compound of the general formula(I) and acid addition salt thereof. (I) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl or optionally substituted C3-C6 membered cycloalkyl containing C3-C8 ; R3, R4, R5, R6 and R7 are independently hydrogen, halogen, hydroxy, nitro, C1-C4 lower ester, C1-C4 lower alkyl, C1-C4 lower alkoxy, aryl, arylalkoxy or unsaturated amine; l is an integer of 0-7; m and n are independently an integer of 0-1; W is carbon or nitrogen; X is oxygen, sulfur, optionally substituted imine; Y is nitrogen or oxygen; and Z is hydrogen, C1-C8 alkoxy, aryloxy, C1-C4 alkylamine, cycloamine containing N1-N5 or oxo group. The present compounds of the above formula (I) has no only strong antimumor activities but lower toxicities, and accordingly are expected as novel antitumor agents.
Bibliography:Application Number: FI19960003566