Substituoituja kinoliinijohdannaisia, menetelmä niiden valmistamseksi

4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, mor...

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Bibliographic Details
Main Authors WINKLER, IRVIN, RIESS, GUENTER, KIRCH, REINHARD, KLEIM, JOERG-PETER, ROESNER, MANFRED
Format Patent
LanguageFinnish
Swedish
Published 14.08.1995
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.
Bibliography:Application Number: FI19950003841