2-heterosyklinenetyyliamiinijohdannaiset ja niiden käyttö lääkkeinä

Compounds of formula I, wherein A represents C=C, S or O; Q represents a 5- or 6-membered unsaturated heterocyclic ring having a nitrogen atom in the position adjacent to the point of attachment, 0-3 further heteroatoms selected from N, O and S, and substituents R6 and R7; R represents H or C PI 1/4...

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Bibliographic Details
Main Authors SCHMIESING, RICHARD JON, MURRAY, ROBERT JOHN, GRIFFITH, RONALD CONRAD
Format Patent
LanguageFinnish
Swedish
Published 28.04.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula I, wherein A represents C=C, S or O; Q represents a 5- or 6-membered unsaturated heterocyclic ring having a nitrogen atom in the position adjacent to the point of attachment, 0-3 further heteroatoms selected from N, O and S, and substituents R6 and R7; R represents H or C PI 1/4 alkyl; R represents H, C PI 1/4 alkyl, C PI 1/4 alkenyl, C PI 1/4 alkynyl, C PI 1/4 cycloalkyl or NH CH CO-; in addition, R and R taken together may form a C PI psi alkylene chain; R represents H, C PI 1/4 alkyl, C PI 1/4 alkenyl, C PI 1/4 alkynyl; R4 and R5 independently represent H, OH, C PI 1/4 alkoxy, C PI 1/4 alkyl, halogen, trifluoromethyl or NR8R9; R6 and R7 independently represent H, OH, C PI 1/4 alkoxy, C PI 1/4 alkyl, halogen, trifluoromethyl, C PI 1/4 hydroxyalkyl, amidino, CONH or NR8R9; in addition, R6 and R7 may independently represent O when substituted on N; R8 and R9 independently represent H or C PI 1/4 alkyl; with various provisos; and pharmaceutically acceptable derivatives thereof; are useful as pharmaceuticals, in particular in the treatment of neurological disorders.
Bibliography:Application Number: FI19940001958