FOERFARANDE FOER FRAMSTAELLNING AV NYA, FARMACEUTISKT AKTIVA BENS(E) INDENDERIVAT

• Main Authors: GIGLER, GABOR, SIMIG, GYULA, SZECSEY NEE HEGEDUS, MARIA, GYERTYAN, ISTVAN, SZEMEREDI, KATALIN, FEKETE, MARTON, ROHACS NEE ZAMKOVAJA, LUDMILLA, PETOCZ, LUJZA, GACSALYI, ISTVAN, SZIRT NEE KISZELLY, ENIKO, REITER NEE ESZES, KLARA, BUDAI, ZOLTAN, BLASKO, GABOR, MEZEI, TIBOR
• Format: Patent
• Language: Finnish
• Published: 29.10.1993
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A subject-matter of the invention are benz[e]indene derivatives of the generel formula wherein A represents a group of the formula in which latter alk means a C2-7 alkylene group, optionally substituted by a hydroxy group and R1 and R2 stand independently for hydrogen or a C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C3-7 cycloalkyl, mono-(C1-7)alkylamino-(C1-7)alkyl or di-(C1-7)alkylamino-(C1-7)alkyl group or R1 and R2 together with the nitrogen atom to which they are attached form a 4 to 7 membered heterocyclic ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may be substituted by a phenyl, benzyl, pyridyl, pyrimidinyl or C1-3 alkyl group which latter ones, in turn, may be substituted by a hydroxy or methoxy group or a halogen atom or a halophenyl group or R1 and R2 together with the nitrogen atom to which they are attached form a phthalimido group or A means a pyrimidino group, a 2,3-(epoxy)-propyl group or a group of the formula in which latter R3 stands for a C1-7 alkyl, C2-7 alkenyl or C3-8 cycloalkyl group and R denotes hydrogen or a C1-7 alkyl group, and their stereoisomers and optically active isomers and mixtures thereof, as well as acid addition salts and quaternary ammonium derivatives of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds.