TETRAHYDROTIOFENDERIVAT

A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the fomula [II] and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a protective group of thiol; R 3 is hydroxy, a remainder...

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Bibliographic Details
Main Authors KATO, NOBUHARU, MORISHITA, MASATAKA, YONEDA, KOJI, MITA, SHIRO, KAWASHIMA, YOICHI, SUHARA, HIROSHI
Format Patent
LanguageFinnish
Published 29.08.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the fomula [II] and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a protective group of thiol; R 3 is hydroxy, a remainder of ester group or a remainder of amido group; A is straight or branched lower alkylene, and the sulfur atom in the side chain may be directly join with -CO- to conform a thiolactone ring. The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.
Bibliography:Application Number: FI19930000873