FOERFARANDE FOER FRAMSTAELLNING AV 1-( (2S)-3-MERKAPTOMETYL-1-OXOPROPYL)L-PROLIN

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). (I) which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) (II) in an inert solvent, in the presence of a catalyst, at a...

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Bibliographic Details
Main Authors UERMOES,NEE LASSU, GABRIELLA, KOVACS NEE PALOTAI, AGNES, DIETZ, ANDRAS, JAKFALVI, ELEMER, BLASKO, GABOR, SCHNEIDER, GEZA, KUN, JUDIT, DINNYES NEE NAGY, ILMA, BECK, IVAN
Format Patent
LanguageFinnish
Published 20.09.1991
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). (I) which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) (II) in an inert solvent, in the presence of a catalyst, at a temperature of 50 DEG to 120 DEG C. under a pressure of 105 to 107 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). (III)
Bibliography:Application Number: FI19910004426