I 17-STAELLNING SUBSTITUERADE KORIKOID-17-ALKYLKARBONATER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE LAEKEMEDEL

• Main Authors: STACHE, ULRICH, DUERKHEIMER, WALTER, PETRI, WALTER, ALPERMANN, HANS GEORG
• Format: Patent
• Language: Finnish
• Published: 11.02.1992
• Edition: 5
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

Corticoid 17-alkyl carbonates of the formula I with A = CHOH in any desired steric arrangement, C=O, CH2; Y = H, F, Cl; Z = H, F, CH3; R(1) = Hal, O-acyl, carbonylalkyl, sulphonic acid alkyl ester, sulphonic acid aryl ester; R(2) = branched alkyl or (CH2)2-4-OCH3 and R(3) = H, methyl, have an excellent local and topical antiinflammatory effect. They are distinguished by a particularly good ratio of local to systemic antiinflammatory activity and, in some cases, also show more potent local antiinflammatory activity than their isomeric corticoid 17-alkyl carbonates with a linear dialkyl group in the 17-alkyl carbonate moiety.