I 17-STAELLNING SUBSTITUERADE KORIKOID-17-ALKYLKARBONATER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA INNEHAOLLANDE LAEKEMEDEL

Corticoid 17-alkyl carbonates of the formula I with A = CHOH in any desired steric arrangement, C=O, CH2; Y = H, F, Cl; Z = H, F, CH3; R(1) = Hal, O-acyl, carbonylalkyl, sulphonic acid alkyl ester, sulphonic acid aryl ester; R(2) = branched alkyl or (CH2)2-4-OCH3 and R(3) = H, methyl, have an excell...

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Bibliographic Details
Main Authors STACHE, ULRICH, DUERKHEIMER, WALTER, PETRI, WALTER, ALPERMANN, HANS GEORG
Format Patent
LanguageFinnish
Published 11.02.1992
Edition5
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Corticoid 17-alkyl carbonates of the formula I with A = CHOH in any desired steric arrangement, C=O, CH2; Y = H, F, Cl; Z = H, F, CH3; R(1) = Hal, O-acyl, carbonylalkyl, sulphonic acid alkyl ester, sulphonic acid aryl ester; R(2) = branched alkyl or (CH2)2-4-OCH3 and R(3) = H, methyl, have an excellent local and topical antiinflammatory effect. They are distinguished by a particularly good ratio of local to systemic antiinflammatory activity and, in some cases, also show more potent local antiinflammatory activity than their isomeric corticoid 17-alkyl carbonates with a linear dialkyl group in the 17-alkyl carbonate moiety.
Bibliography:Application Number: FI19910003775