FOERFARANDE FOER FRAMSTAELLNING AV ANTIHYPERTENSIVA HYDRAZINDERIVAT

• Main Authors: GALONS, HERVE, MIOCQUE, MARCEL, BINET, PIERRE
• Format: Patent
• Language: Finnish
• Published: 15.11.1988
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Hydrazine derivatives corresponding to the formula: in which: X is a C1-C4 alkyl, the trifluoromethyl group or a halogen chosen from chlorine (in ortho or meta position), fluorine or bromine, R1 is a C1-C4 alkyl group; R2 denotes: - hydrogen, - a C3-C4 branched alkyl group, - a C1-C4 alkoxy, preferably ethoxy group, - a group of formula CR3R4R5 in which: R3 denotes an OR6, SR6 or NR7R8 group in which: R6 is hydrogen or a C1-C4 alkyl, R7 and R8 denote hydrogen, a C1-C4 alkyl group, a C2-C4 acyl group, a benzoyl group or else R7 and R8 together with the nitrogen atom to which they are bonded form a 5- or 6-membered heterocyclic group; R4 and R5 are identical and denote hydrogen or a C1-C4 alkyl group or else R4 is hydrogen and R5 denotes either a C1-C4 alkyl group optionally substituted by a hydroxyl group or a phenyl group, or else R3, R4 and R5 together with the carbon atom to which they are bonded form an amido group; - a phenyl group optionally substituted by a hydroxyl group; - a 5- or 6-membered heterocyclic group and the pharmaceutically acceptable salts of the said compounds.