ISOTIURONIUM-SALTER

The invention relates to a process for the preparation of isothiuronium salts with the general formula (I) where R1 is a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, arylalkyl or aryl group, these groups being optionally substituted with one or more hydroxyl groups, mercapto groups a...

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Bibliographic Details
Main Authors VERTESI, CSABA, GUCZOGHY, LAJOS, MOLNAR, ATTILA
Format Patent
LanguageFinnish
Published 03.12.1985
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a process for the preparation of isothiuronium salts with the general formula (I) where R1 is a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, arylalkyl or aryl group, these groups being optionally substituted with one or more hydroxyl groups, mercapto groups and/or halogen atoms, R2 is hydrogen, a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl group, and X represents an organic or inorganic anion. The compounds according to the invention can be prepared by reacting a compound with formula II II with an alkylating agent capable of introducing an R1 group. Compounds with the general formula I exhibit antitumour and immuno-stimulating activities and are useful in therapy.
Bibliography:Application Number: FI19850004790