FOERFARANDE FOER FRAMSTAELLNING AV A-RISTOMYCIN OCH/ELLER RISTOMYCINDERIVAT MED HOEG RENHETSGRAD SAREAGENS INNEHAOLLANDE NAEMNDA FOERENING(AR) FOER TROMBOCYTENAGGREGATIONSFOERSOEK

The invention relates to a process for the preparation of A-ristomycin salts and/or A-ristomycin and/or derivatives thereof of high purity of the general formula I of Patent Claim 1, in which R1, R2, R3, R4, X and Y are defined as in Claim 1, in which I) the pH of an aqueous solution of the crude ri...

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Bibliographic Details
Main Authors BODA, ZOLTAN, ZAJKA, GABRIELLA, RAK, KALMAN, SZTARICSKAI, FERENC, BOGNAR, REZSO
Format Patent
LanguageFinnish
Published 22.03.1984
Edition3
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The invention relates to a process for the preparation of A-ristomycin salts and/or A-ristomycin and/or derivatives thereof of high purity of the general formula I of Patent Claim 1, in which R1, R2, R3, R4, X and Y are defined as in Claim 1, in which I) the pH of an aqueous solution of the crude ristomycin base is adjusted with a mineral acid, or of an impure A-ristomycin salt is adjusted with an alkali solution, to 6.7 to 7.0, and the solution is treated with a carbonitrile, and the A-ristomycin salt and/or A-ristomycin is crystallised and, where appropriate, dissolved or suspended in an organic solvent and then acylated or II) a solution or suspension of a crude A-ristomycin salt or of crude ristomycin base or of a crude ristomycin salt in an organic solvent is acylated, and the resulting products are isolated. The invention also relates to reagents containing these compounds and to a process for the preparation of the reagents.
Bibliography:Application Number: FI19830003388