NYA 13-TIOPROSTACYKLINDERIVAT OCH FOERFARANDE FOER DERAS FRAMSTAELLNING

The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I I. wherein R1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms; R2 is straight or branched chain alkyl having 4-9 carbon at...

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Bibliographic Details
Main Authors NOVAK, LAJOS, GALAMBOS, GEZA, SZANTAY, CSABA, VIRAG, SANDOR, ASZODI, JOZSEF, SIMONIDESZ, VILMOS, STADLER, ISTVAN, KOERMOECZY, PETER, KOVACS, GABOR
Format Patent
LanguageFinnish
Published 23.10.1982
Edition3
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I I. wherein R1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms; R2 is straight or branched chain alkyl having 4-9 carbon atoms or monosubstituted phenoxymethyl; -A-B- is -CH2-CH2-, -CH=CH- of Z- or E- configuration or -C 3BOND C-; one of the symbols X and Y is hydrogen, methyl or ethyl and the other is hydroxy, tetrahydropyranyoxy, 1-ethoxy-ethoxy or trialkylsilyloxy; or X and Y together form a -O-CH2-CH2-O- group; Z is a sulfur atom or a -SO- group. The compounds of the Formula I can be prepared by reacting a 13-thia-prostaglandine of the Formula III III.
Bibliography:Application Number: FI19820001361