FOERFARANDE FOER FRAMSTAELLNING AV OPTISKT AKTIVA ELLER RACEMISKA LAKTONDIOLDERIVAT

The invention 1s concerned with a novel process for producing compounds of formula 1 I wherein R3 and R4 are the same or different and each represent hydrogen or a lower alkanoyl group whlich is unsubstituted or is substituted by one, two or three halogen atoms, or R3 and R4 together form a qroup R5...

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Main Authors SZEKELY ISTVAN, KERESZTES BORBALA, STADLER ISTVAN, TOEMOESKOEZI ISTVAN, KOVACS GABOR, LOVASZ MARIANN, SIMONIDESZ VILMOS, SZANTAY CSABA, REMPORT JULIA, VISKY ZSUZSA
Format Patent
LanguageFinnish
Published 10.12.1985
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention 1s concerned with a novel process for producing compounds of formula 1 I wherein R3 and R4 are the same or different and each represent hydrogen or a lower alkanoyl group whlich is unsubstituted or is substituted by one, two or three halogen atoms, or R3 and R4 together form a qroup R5-?-R6 wherelin R5 and R6 are the same or different and each represent hydrogen or a methyl or phenyl group, with the proviso that when one of R5 and R6 is phenyl the other is hydrogen. The compounds of formula I are obtained by reacting a lactone of formula II II with formaldehyde or a polymer of formaldehyde in the procence of a strong acid, followed, if necessary, by reaction with a compound of formula R5COR6 or R5CHO or an acetal thereof. The compounds of formula I are useful lntermediates in Corey's synthesis of prostaglandins and those compounds in which R3 and R4 form a group ,5-?-R are novel.
Bibliography:Application Number: FI19770000531