GEMINALA DIHALOGENDERIVAT AV KONDENSERADE PYRIMIDIN-4-ONER VILKA AER MELLANPRODUKTER VID FRAMSTAELLNING AV TERAPEUTISKT ANAENDBARA 9-AMINOPYRIDO(1,2-A)PYRIMIDIN- OCH 9-HYDRATSONO- 6,,8,9-TETRAHYDRO-4H-PYRIDO(1,2-A)PYRIMIDINDERIVAT

• Main Authors: HORVATH AGNES, BREINING TIBOR, HERMECZ ISTVAN, KOEKOESI JOZSEF, VASVARI NEE DEBRECZY LELLE, MESZAROS ZOLTAN, BITTER ISTVAN
• Format: Patent
• Language: Finnish
• Published: 11.11.1985
• Edition: 4
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; LAKES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; MORDANTS; NATURAL RESINS; ORGANIC CHEMISTRY; ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Geminal dihalogen derivatives of condensed pyrimidine-4-one compounds of the general formula [wherein R represents hydrogen, lower alkyl, or lower alkoxycarbonyl; R represents hydrogen, lower alkyl, ester group, carboxy or a derivative thereof, cyano, phenyl or halogen; R represents hydrogen, lower alkyl or phenyl; X represents halogen; n is the integer 0, 1 or 2] and the salts and optically active antipodes thereof are of interest as chemical intermediates; some also exhibit a variety of physiological activities and may be formulated into pharmaceutical compositions in conventional manner. The novel compounds can be made by halogenating a corresponding starting material wherein one or both X-substituents are hydrogen.