FOERFARANDE FOER FRAMSTAELLNING AV EN NY FARMAKOLOGISKT AKTIV 1-FENYL-2-(FENOXI-ISOPROPYLAMINO)-1,3-PROPANDIOL

• Main Authors: PETOCZ LUJZA, LEVAI LASZLO, FAZEKAS GABOR, GRASSER KATALIN
• Format: Patent
• Language: Finnish
• Published: 11.03.1985
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to novel 1-phenyl-2-amino-1,3-propanediol-N-alkyl derivatives having the general formula I (I) wherein R1 is hydrogen, alkyl having from 1 to 8 carbon atoms or phenoxymethyl, and R2 is hydrogen, alkyl having from 1 to 8 carbon atoms or 2,2-diphenylethyl, with the proviso that if R1 is phenoxymethyl then R2 may stand only for methyl, and if R2 is 2,2-diphenylethyl then R1 may stand only for hydrogen, and its isomers and pharmaceutically acceptable salts. Furthermore, the invention relates to a process for preparing these compounds. The novel 1-phenyl-2-amino-1,3-propanediol-N-alkyl derivatives having the general formula I possess significant anti-anginose activity and show several other biological activities.