LONG-ACTING GROWTH HORMONE AND METHODS OF PRODUCING SAME

A chorionic gonadotropin carboxy terminal peptide (CTP)-modified polypeptide comprising a growth hormone for use in a method of reducing the dosing frequency of a growth hormone in a human adult subject, wherein the CTP-modified polypeptide comprises one chorionic gonadotropin carboxy terminal pepti...

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Bibliographic Details
Main Authors FARES, Fuad, FIMA, Udi Eyal
Format Patent
LanguageEnglish
Finnish
Published 16.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A chorionic gonadotropin carboxy terminal peptide (CTP)-modified polypeptide comprising a growth hormone for use in a method of reducing the dosing frequency of a growth hormone in a human adult subject, wherein the CTP-modified polypeptide comprises one chorionic gonadotropin carboxy terminal peptide (CTP) attached to the amino terminus of the growth hormone, and two chorionic gonadotropin CTPs attached to the carboxy terminus of the growth hormone, and optionally a signal peptide attached to the amino terminus of the amino terminal CTP, wherein the method comprises administering to the subject a therapeutically effective amount of the CTP-modified polypeptide.
Bibliography:Application Number: FI20190008355T