FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS

The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative d...

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Main Authors LEE, Minwoo, KIM, Hye, SEO, Jeongbeob, LEE, Gilnam, KIM, Moonsoo, CHOI, Hyang, YOON, Cheolhwan, JUNG, Myung, LEE, Jae, KIM, Misoon, KIM, Jay, KIM, Hyun, CHOI, Soongyu, LEE, Chaewoon, JEONG, Hankyul, LEE, Ki
Format Patent
LanguageEnglish
Finnish
Published 10.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases.In some compounds of Formula I, Q is -CH=CR3C(O)NR4R5, -C≡CC(O)NR4R5, or
Bibliography:Application Number: FI20150869420T