SILA-ANALOGOS DE COMPUESTOS DE VITAMINA D, METODO DE PRODUCCION DE DICHOS COMPUESTOS Y USOS DE LOS MISMOS

• Main Authors: Rodriguez, Borges, Loureiro Martinez, Julian, Perez Fernandez, Roman, Sampaio Dias, Ivo Emmanuel, Romao de Castro, Baltazar Manuel, Mouriño Mosquera, Antonio, Seoane Ruzo, Samuel
• Format: Patent
• Language: Spanish
• Published: 16.08.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present application describes the synthesis and important biological applications of novel vitamin D analogues with a carbon-to-silicon exchange in the side chain of the natural hormone and its analogues. In comparison to the natural metabolite 1α,25-dihydroxyvitamin D3 (1,25D) of the vitamin D receptor (VDR), the key biological results of these novel derivatives indicate that: a) these analogues show a similar cell differentiation, b) the proliferation of tumoral cell lines are significantly lower, c) great ability to activate target genes of 1,25D and d) high affinity to the VDR. Furthermore, one of the analogues induces a significant increase in the weight of some animals, which may suggest an increase in bone density.