Métodos de tratamiento de enfermedades asociadas a S. aureus

• Main Authors: SELLMAN, Bret, TKACZYK, Christine, HUA, Lei, HAMILTON, Melissa
• Format: Patent
• Language: Spanish
• Published: 25.05.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Un anticuerpo antitoxina α (anti-AT) de S. aureus aislado para su uso en la reducción de la intensidad de una neumonía asociada a S. aureus en un sujeto mamífero inmunodeprimido, en el que la CDR1 de VH, CDR2 de VH, CDR3 de VH, CDR1 de VL, CDR2 de VL y CDR3 de VL comprenden las secuencias de aminoácidos de los SEQ ID NO: 69, 70, 71, 1, 2 y 68. The present invention provides for methods of preventing and/or treating S. aureus-associated bacteremia and sepsis, and methods for preventing and/or treating S. aureus-associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (anti-AT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus associated pneumonia in an immunocompromised mammalian subject.