Métodos de beta-glucano y composiciones que afectan al microentorno tumoral

• Main Authors: GRAFF, Jeremy, BYKOWSKI JONAS, Adria, KANGAS, Takashi, GORDEN, Keith, QIU, Xiaohong, FRASER, Kathryn A, OTTOSON, Nadine, LEONARDO, Steven, CHAN, Anissa SH, BOSE, Nandita
• Format: Patent
• Language: Spanish
• Published: 10.11.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

β(1,6)-[Poli-(1,3)-D-glucopiranosil]-poli-β(1,3)-D-glucopiranosa soluble y un anticuerpo anti-PD-1 para su uso en un método de tratamiento de un sujeto que tiene cáncer, en donde el anticuerpo anti-PD-1 es un inhibidor del punto de control inmunitario. This disclosure relates to the combination of soluble β-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble β-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-angiogenics, checkpoint inhibitors including non-tumor targeting antibodies.