Composiciones anti CGRP y uso de las mismas

Método para producir un anticuerpo anti CGRP, método que comprende expresar los polinucleótidos de las secuencias SEQ ID NO:192 y SEQ ID NO:194 en células de levadura o en células de mamífero. The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP....

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Main Authors LATHAM, John A, MCNEILL, Patricia Dianne, DUTZAR, Benjamin H, LOOMIS, Maria-Cristina, BILLGREN, Jens J, KOVACEVICH, Brian Robert, JANSON, Nicole M, MITCHELL, Danielle M, GARCIA-MARTINEZ, Leon F, OLSON, Katie
Format Patent
LanguageSpanish
Published 04.11.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Método para producir un anticuerpo anti CGRP, método que comprende expresar los polinucleótidos de las secuencias SEQ ID NO:192 y SEQ ID NO:194 en células de levadura o en células de mamífero. The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
Bibliography:Application Number: ES20190215303T