Polipéptido FGF2 termoestable, utilización del mismo

Polipéptido termoestable que posee actividad de FGF2 y que tiene, como mínimo, el 85 % de identidad de secuencia con la SEQ ID NO: 2, y que comprende, como mínimo, una sustitución de aminoácidos R31L. The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at...

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Main Authors KREJCI, Pavel, BALEK, Lukas, STEPANKOVA, Veronika, DAMBORSKY, Jiri, VANACEK, Pavel, BREZOVSKY, Jan, SEBESTOVA, Eva, BEDNAR, David, DVORAK, Petr, CHALOUPKOVA, Radka, BOSAKOVA, Michaela, KONECNA, Zaneta, DVORAK, Pavel, EISELLEOVA, Livia, PROKOP, Zbynek
Format Patent
LanguageSpanish
Published 12.05.2021
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Polipéptido termoestable que posee actividad de FGF2 y que tiene, como mínimo, el 85 % de identidad de secuencia con la SEQ ID NO: 2, y que comprende, como mínimo, una sustitución de aminoácidos R31L. The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
Bibliography:Application Number: ES20160781318T