Formas sólidas y formulaciones de (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin-2-il)benzamida

• Main Authors: KREJSA, Cecile, INGALLINERA, Tim, BLATTER, Fritz, BARF, Tjeerd, EVARTS, Jerry, ARET, Edwin
• Format: Patent
• Language: Spanish
• Published: 04.12.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Una composición que comprende (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin- 2-il)benzamida cristalina en donde la base libre de (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin- 1-il)-N-(piridin-2-il)benzamida cristalina se caracteriza por un patrón de difracción de rayos X en polvo de transmisión que comprende picos a 6,4, 8,6, 10,5, 11,6, y 15,7 °2θ ± 0,2 °2θ, en donde el patrón de difracción de rayos X en polvo se adquirió usando fuente de radiación Cu-Kα1. In some embodiments, the invention relates to crystalline solid forms, including polymorphs, hydrates, and salt forms, of (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide. In some embodiments, the invention also relates to pharmaceutical compositions containing the crystalline solid forms, and methods for treating conditions or disorders by administering to a subject a pharmaceutical composition that includes the forms, including pharmaceutical compositions and methods for overcoming the effects of acid reducing agents.