Inmunoconjugados de antimesotelina y usos de los mismos

• Main Authors: KOPITZ, Charlotte Christine, SCHUHMACHER, Joachim, HEISLER, Iring, UNTERSMANN, Kerstin, KAHNERT, Antje
• Format: Patent
• Language: Spanish
• Published: 29.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Un inmunoconjugado que comprende un agente citotóxico y un anticuerpo humano o humanizado, en el que dicho anticuerpo comprende: i) una secuencia de cadena pesada variable de SEQ ID NO: 23 y una secuencia de cadena ligera variable de SEQ ID NO: 27, o ii) una secuencia de cadena pesada variable de SEQ ID NO: 20 y una secuencia de cadena ligera variable de SEQ ID NO: 24 o iii) una secuencia de cadena pesada variable de SEQ ID NO: 21 y una secuencia de cadena ligera variable de SEQ ID NO: 25, y en el que el agente citotóxico es un maitasinoide. The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors.recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells