IGFBP7 para la predicción del riesgo de LRA cuando se mide antes de una intervención quirúrgica

• Main Authors: SOUKUPOVA, Monika, HORSCH, Andrea, KIENTSCH-ENGEL, Rosemarie, KAISER, Anna Edelgard, KARL, Johann, BLOCK, Dirk, MANUILOVA, Ekaterina, KASTNER, Peter, RABE, Christina, WIENHUES-THELEN, Ursula-Henrike, ENGEL, Alfred, KLAPPERICH, Birgit, RUTZ, Sandra
• Format: Patent
• Language: Spanish
• Published: 23.07.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

Un procedimiento para predecir el riesgo de que un paciente sufra una lesión renal aguda (LRA) durante o después de un procedimiento quirúrgico, o de que sufra una lesión renal aguda (LRA) después de la administración de un medio de contraste, que comprende las etapas de: (a) determinar la cantidad del biomarcador IGFBP7 (proteína de unión al factor de crecimiento insulínico 7) en una muestra de sangre, suero o plasma del paciente antes de dicho procedimiento quirúrgico o antes de dicha administración de un medio de contraste, y (b) comparar la cantidad determinada de dicho biomarcador con una referencia. The present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) during or after a surgical procedure or after administration of a contrast medium. The method is based on the determination of the level of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) in a body fluid sample obtained from the patient prior to the surgical procedure or prior to the administration of a contrast medium. Further, the present disclosure describes a method for predicting the risk of a patient to suffer from acute kidney injury (AKI) based on the determination of the amount of the biomarker IGFBP7 (Insulin-like Growth Factor Binding Protein 7) and Cystatin C in a body fluid sample obtained from the patient. The present disclosure further encompasses kits and devices adapted to carry out the methods of the disclosed methods.