Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP)

Una combinacion que comprende un compuesto de formula I:**Fórmula** en la que: R1 es hidrogeno o fluor; y R2 es hidrogeno o fluor; o una sal, un estereoisomero o un tautomero del mismo y uno o mas agentes antineoplasicos. The present invention relates to compounds of formula (I): and pharmaceuticall...

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Bibliographic Details
Main Authors Schultz-Fademrecht, Carsten, Jones, Philip, Ontoria Ontoria, Jesus Maria, Scarpeli, Rita
Format Patent
LanguageSpanish
Published 22.10.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Una combinacion que comprende un compuesto de formula I:**Fórmula** en la que: R1 es hidrogeno o fluor; y R2 es hidrogeno o fluor; o una sal, un estereoisomero o un tautomero del mismo y uno o mas agentes antineoplasicos. The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory discuses, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo and/or radiosensitizers for cancer treatment.
Bibliography:Application Number: ES20140176452T