Aptámeros contra EGFR y sus usos terapéuticos

Una molécula de ácido ribonucleico que comprende la secuencia de nucleótidos 5'-mGmG mG mAfUfU fUAA fUfCmG fCfCmG fUmAmG AmAmA AmGfC mAfUmG fUfCmA AAmG fCfCmG mGmAA fCfCfC-3' (ALT102139.01) (SEQ ID NO: 79), en donde "m" representa un nucleótido sustituido con 2'-O-metilo y &...

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Bibliographic Details
Main Authors HATALA, Paul, HALL, Bradley
Format Patent
LanguageSpanish
Published 10.09.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Una molécula de ácido ribonucleico que comprende la secuencia de nucleótidos 5'-mGmG mG mAfUfU fUAA fUfCmG fCfCmG fUmAmG AmAmA AmGfC mAfUmG fUfCmA AAmG fCfCmG mGmAA fCfCfC-3' (ALT102139.01) (SEQ ID NO: 79), en donde "m" representa un nucleótido sustituido con 2'-O-metilo y "f" representa un nucleótido sustituido con 2'-fluoro. The invention relates to novel aptamers, in particular aptamers which are capable of binding to EGFR. The invention also relates to cancer cell binding complexes comprising said aptamers and the use of said cancer cell binding complexes in the treatment of cancer.
Bibliography:Application Number: ES20150732901T