Derivados de piperidinona como inhibidores de MDM2 para el tratamiento de cáncer

The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

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Main Authors Gustin, Darin James, McGee, Lawrence, Yan, Xuelei, Gribble, jr. Michael William, Beck, Hilary Plake, McMinn, Dustin, Zhu, Jiang, Chen, Xiaoqi, Heath, Julie Anne, Li, Zhihong, Mihalic, Jeffrey Thomas, Jiao, Xianjun, Lai, SuJen, Fu, Zice, Ma, Zhihua, Deignan, Jeffery, Wang, Xiaodong, Huang, Xin, Eksterowicz, John, Roveto, Philip Marley, Yu, Ming, Kayser, Frank, Kopecky, David John, Gonzalez Lopez de Turiso, Felix, McIntosh, Joel, Connors, Richard Victor, Olson, Steven Howard, Gonzalez Buenrostro, Ana, Duquette, Jason, Fu, Jiasheng, Liu, Jiwen, Low, Jonathan Dante, Li, Yihong, Fox, Brian Matthew, Bartberger, Michael David, Sun, Daqing, Wang, Yingcai, Medina, Julio Cesar, Fisher, Benjamin, Johnson, Michael, Lucas, Brian Stuart, Rew, Yosup
Format Patent
LanguageSpanish
Published 20.06.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
AbstractList The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Author Gribble, jr. Michael William
Lai, SuJen
Eksterowicz, John
Wang, Yingcai
Liu, Jiwen
Bartberger, Michael David
McGee, Lawrence
Roveto, Philip Marley
Medina, Julio Cesar
Olson, Steven Howard
Rew, Yosup
Zhu, Jiang
Chen, Xiaoqi
Fu, Zice
Mihalic, Jeffrey Thomas
Yu, Ming
Gustin, Darin James
Johnson, Michael
Ma, Zhihua
Sun, Daqing
Yan, Xuelei
Beck, Hilary Plake
Fox, Brian Matthew
McMinn, Dustin
Jiao, Xianjun
Li, Zhihong
Deignan, Jeffery
Duquette, Jason
McIntosh, Joel
Wang, Xiaodong
Gonzalez Lopez de Turiso, Felix
Heath, Julie Anne
Kayser, Frank
Low, Jonathan Dante
Connors, Richard Victor
Gonzalez Buenrostro, Ana
Huang, Xin
Li, Yihong
Kopecky, David John
Lucas, Brian Stuart
Fu, Jiasheng
Fisher, Benjamin
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– fullname: McGee, Lawrence
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– fullname: Gribble, jr. Michael William
– fullname: Beck, Hilary Plake
– fullname: McMinn, Dustin
– fullname: Zhu, Jiang
– fullname: Chen, Xiaoqi
– fullname: Heath, Julie Anne
– fullname: Li, Zhihong
– fullname: Mihalic, Jeffrey Thomas
– fullname: Jiao, Xianjun
– fullname: Lai, SuJen
– fullname: Fu, Zice
– fullname: Ma, Zhihua
– fullname: Deignan, Jeffery
– fullname: Wang, Xiaodong
– fullname: Huang, Xin
– fullname: Eksterowicz, John
– fullname: Roveto, Philip Marley
– fullname: Yu, Ming
– fullname: Kayser, Frank
– fullname: Kopecky, David John
– fullname: Gonzalez Lopez de Turiso, Felix
– fullname: McIntosh, Joel
– fullname: Connors, Richard Victor
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– fullname: Liu, Jiwen
– fullname: Low, Jonathan Dante
– fullname: Li, Yihong
– fullname: Fox, Brian Matthew
– fullname: Bartberger, Michael David
– fullname: Sun, Daqing
– fullname: Wang, Yingcai
– fullname: Medina, Julio Cesar
– fullname: Fisher, Benjamin
– fullname: Johnson, Michael
– fullname: Lucas, Brian Stuart
– fullname: Rew, Yosup
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Snippet The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Derivados de piperidinona como inhibidores de MDM2 para el tratamiento de cáncer
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