Derivados de piperidinona como inhibidores de MDM2 para el tratamiento de cáncer

• Main Authors: Gustin, Darin James, McGee, Lawrence, Yan, Xuelei, Gribble, jr. Michael William, Beck, Hilary Plake, McMinn, Dustin, Zhu, Jiang, Chen, Xiaoqi, Heath, Julie Anne, Li, Zhihong, Mihalic, Jeffrey Thomas, Jiao, Xianjun, Lai, SuJen, Fu, Zice, Ma, Zhihua, Deignan, Jeffery, Wang, Xiaodong, Huang, Xin, Eksterowicz, John, Roveto, Philip Marley, Yu, Ming, Kayser, Frank, Kopecky, David John, Gonzalez Lopez de Turiso, Felix, McIntosh, Joel, Connors, Richard Victor, Olson, Steven Howard, Gonzalez Buenrostro, Ana, Duquette, Jason, Fu, Jiasheng, Liu, Jiwen, Low, Jonathan Dante, Li, Yihong, Fox, Brian Matthew, Bartberger, Michael David, Sun, Daqing, Wang, Yingcai, Medina, Julio Cesar, Fisher, Benjamin, Johnson, Michael, Lucas, Brian Stuart, Rew, Yosup
• Format: Patent
• Language: Spanish
• Published: 20.06.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.