PROCEDURE FOR PREPARING ACID METHYL ESTERTER 3 - [(4S) -8-BROMO-1-METHYL-6- (PYRIDIN-2-IL) -4H-IMIDAZO [1,2-A] [1,4] BENZODIAZEPIN-4 -IL] -PROPIONIC, AND USEFUL COMPOUNDS IN THAT PROCEDURE (Machine-translation by Google Translate, not legally binding)

• Main Authors: DOBARRO RODRIGUEZ, Alicia, SANCHEZ CASALS, Carles
• Format: Patent
• Language: English; Spanish
• Published: 15.04.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Procedure for preparing 3 - [(4S) -8-bromo-1-methyl-6- (pyridin-2-yl) -4H-imidazo [1,2-a] [1,4] benzodiazepin-4-methyl ester -yl] -propionic, and compounds useful in that procedure. The present invention relates to a process for preparing methyl ester of 3 - [(4S) -8-bromo-1-methyl-6- (pyridin-2-yl) -4H-imidazo [1,2-a] [ 1,4] benzodiazepin-4-yl] -propionic acid, starting from the methyl ester of 3 - [(3S) -7-bromo-2-oxo-5- (pyridin-2-yl) -2,3-dihydro- 1H- [1,4] -benzodiazepin-3-yl] propionic, and new compounds useful as intermediates in that process, the methyl ester of (3S) -3- [7-bromo-2- (2,2-dimethoxypropylamino) -5-pyridin-2-yl-3H-benzo [e] [1,4] diazepin-3-yl] propionic acid. (Machine-translation by Google Translate, not legally binding) Procedimiento para preparar metil éster de ácido 3-[(4S)-8-bromo-1-metil-6-(piridin-2-il)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propiónico, y compuestos útiles en ese procedimiento. La presente invención se relaciona con un procedimiento para preparar metil éster del ácido 3-[(4S)-8-bromo-1-metil-6-(piridin-2-il)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propiónico, partiendo del éster metílico del ácido 3-[(3S)-7-bromo-2-oxo-5-(piridin-2-il)-2,3-dihidro-1H-[1,4]-benzodiazepin-3-il] propiónico, y nuevos compuestos útiles como intermedios en ese procedimiento, el metil éster de ácido (3S)-3-[7-bromo-2-(2,2-dimetoxipropilamino)-5-piridin-2-il-3H-benzo[e][1,4]diazepin-3-il]propiónico.