Enfermedad cardiovascular

• Main Authors: ELOSUA LLANOS, Roberto, SALGADO GOMEZ, Joan, SALAS PEREZ-RASILLA, Eduardo, MARRUGAT DE LA IGLESIA, Jaume, CASTILLO FERNANDEZ, Sergio, ORDOVAS MUNOZ, José Maria
• Format: Patent
• Language: Spanish
• Published: 06.03.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

Método para una evaluación del riesgo cardiovascular en un sujeto, que comprende las etapas de determinar en una muestra aislada de dicho sujeto la presencia de polimorfismos en las posiciones 27 dentro de cada una de las secuencias de ácido nucleico de SEQ ID NO: 1 a 8, en el que la presencia en la posición 27 es C en SEQ ID NO: 1, C en SEQ ID NO: 2, T en SEQ ID NO: 3, C en SEQ ID NO: 4, C en SEQ ID NO: 5, C en SEQ ID NO: 6, T en SEQ ID NO: 7 y G en SEQ ID NO: 8, es indicativa de un riesgo de padecer un acontecimiento cardiovascular, en el que el acontecimiento cardiovascular se selecciona del grupo de infarto de miocardio, accidente cerebrovascular, angina de pecho, ataques isquémicos transitorios, arteriopatía periférica mortales o no mortales o una combinación de los mismos. The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.