Expresión de proteínas humanas recombinantes en Tetrahymena

Procedimiento para la producción de glicoproteínas humanas recombinantes en Tetrahymena, que comprende las etapas: a) transformación de células de Tetrahymena con ADN recombinante, que comprende al menos un gen funcional que codifica para una glicoproteína humana, b) cultivo de las células recombina...

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Bibliographic Details
Main Authors KIY, Thomas, RÜSING, Matthias
Format Patent
LanguageSpanish
Published 08.08.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Procedimiento para la producción de glicoproteínas humanas recombinantes en Tetrahymena, que comprende las etapas: a) transformación de células de Tetrahymena con ADN recombinante, que comprende al menos un gen funcional que codifica para una glicoproteína humana, b) cultivo de las células recombinantes de Tetrahymena y expresión del gen, y c) aislamiento de las glicoproteínas New recombinant Tetrahymena cells comprising DNA encoding a recombinant human protein (I), that express a human gene, or which secrete a recombinant human protein. Independent claims are also included for the following: (1) recombinant human proteins that have the glycosylation pattern typical of Tetrahymena; and (2) a vector, for expressing human proteins in Tetrahymena, that includes a human leader sequence.
Bibliography:Application Number: ES20030007097T