Procedure for the deoxygenation of N-oxides of pyridine, quinoline and isoquinoline. (Machine-translation by Google Translate, not legally binding)

• Main Authors: Arnáiz García, Francisco Javier, Sanz Díez, Roberto, Pedrosa Sáez, María Remedios, Rubio Presa, Rubén, Fernández Rodríguez, Manuel Angel
• Format: Patent
• Language: English; Spanish
• Published: 20.07.2017
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The present invention relates to a process for the catalytic deoxygenation of N-oxides of pyridine, quinoline and isoquinoline to the corresponding heterocyclic compounds derived from pyridine, quinoline and isoquinoline, by the use of pinacol (2,3-dimethyl-2,3 -butanediol) as a reducing agent in the presence of a molybdenum (VI) catalyst, in an organic solvent, at atmospheric pressure and at a temperature of 130ºC or, alternatively, by irradiation in a single-mode microwave oven at a maximum power of 150 w and at a temperature of 130º c, generating as main byproducts water and acetone. (Machine-translation by Google Translate, not legally binding) La presente invención se refiere a un procedimiento para la desoxigenación catalítica de N-óxidos de piridina, quinolina e isoquinolina a los correspondientes compuestos heterocícicos derivados de piridina, quinolina e isoquinolina, mediante la utilización de pinacol (2,3-dimetil-2,3-butanodiol) como agente reductor en presencia de un catalizador de molibdeno (VI), en un disolvente orgánico, a presión atmosférica y a una temperatura de 130ºC o, alternativamente, por irradiación en un horno microondas monomodo a una potencia máxima de 150 W y a una temperatura de 130°C, generando como principales subproductos agua y acetona.