Bacterial strain of micromonospora matsumotoense producer of paulomycin and paulomycin produced by the same (Machine-translation by Google Translate, not legally binding)

• Main Authors: BLANCO BLANCO, María Gloria, REYES BENITEZ, José Fernando, ACUNA FERNANDEZ, José Luis, FERNANDEZ BRANA, Alfredo Javier, PEREZ-VICTORIA MORENO DE BARREDA, Ignacio, VICENTE PEREZ, María Francisca, GARCIA DIAZ, Luis Arsenio, MARTIN SERRANO, Jesús Melchor, SARMIENTO VIZCAINO, Aida, DE PEDRO MONTEJO, Nuria
• Format: Patent
• Language: English; Spanish
• Published: 25.05.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Bacterial strain of micromonospora matsumotoense producer of paulomycins and paulomycin produced by it. The invention provides a new bacterial strain of micromonospora matsumotoense isolated from its natural environment and deposited in the spanish type culture collection under the access number (cect 9281), which is capable of efficiently producing an antitumor compound of the family of fermentation by fermentation. The paulomycins. Specifically, this strain is a producer of a new paulomycin, designated in the present invention as paulomycin g, which has cytotoxic activity against tumor cells, preferably human, preferably of pancreas, breast and liver. (Machine-translation by Google Translate, not legally binding) Cepa bacteriana de Micromonospora matsumotoense productora de paulomicinas y paulomicina producida por la misma. La invención proporciona una nueva cepa bacteriana de Micromonospora matsumotoense aislada de su medio natural y depositada en la Colección Española de Cultivos Tipo bajo el número de acceso (CECT 9281), la cual es capaz de producir eficientemente por fermentación un compuesto antitumoral de la familia de las paulomicinas. Concretamente, esta cepa es productora de una nueva paulomicina, designada en la presente invención como paulomicina G, que presenta actividad citotóxica frente a células tumorales, preferiblemente humanas, preferiblemente de páncreas, mama e hígado.