Bacterial strain of streptomyces carnosus producer of loboforins and loboforin produced by it. (Machine-translation by Google Translate, not legally binding)

• Main Authors: BLANCO BLANCO, María Gloria, REYES BENITEZ, José Fernando, DE LA CRUZ MORENO, Mercedes, FERNANDEZ BRANA, Alfredo Javier, PEREZ-VICTORIA MORENO DE BARREDA, Ignacio, VICENTE PEREZ, María Francisca, GARCIA DIAZ, Luis Arsenio, MARTIN SERRANO, Jesús Melchor, SARMIENTO VIZCAINO, Aida, DE PEDRO MONTEJO, Nuria, OSSET ALVAREZ, Miguel
• Format: Patent
• Language: English; Spanish
• Published: 10.03.2017
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SUGARS

Bacterial strain of streptomyces carnosus that produces loboforins and loboforin produced by it. The invention provides a new bacterial strain of streptomyces carnosus that has been isolated from its natural environment and deposited in the spanish type culture collection under accession number 9162, which is capable of efficiently producing by fermentation antibiotic compounds of the family of the loboforinas. Specifically, this strain is a producer of a new loboforin, designated in the present invention as loboforin k, which has cytotoxic activity against tumor cells, preferably human, and antibiotic or antibacterial activity against pathogenic gram-positive bacteria, preferably human. (Machine-translation by Google Translate, not legally binding) Cepa bacteriana de Streptomyces carnosus productora de loboforinas y loboforina producida por la misma. La invención proporciona una nueva cepa bacteriana de Streptomyces carnosus que ha sido aislada de su medio natural y depositada en la Colección Española de Cultivos Tipo bajo el número de acceso 9162, la cual es capaz de producir eficientemente por fermentación compuestos antibióticos de la familia de las loboforinas. Concretamente, esta cepa es productora de una nueva loboforina, designada en la presente invención como loboforina K, que presenta actividad citotóxica frente a células tumorales, preferiblemente humanas, y actividad antibiótica o antibacteriana frente a bacterias patógenas Gram-positivas, preferiblemente humanas.