Receptores de linfocitos T con alta afinidad por el VIH

• Main Authors: Jakobsen, Bent Karsten, Dunn, Steven Mark, Molloy, Peter Eamon, Li, Yi
• Format: Patent
• Language: Spanish
• Published: 31.01.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Un receptor de linfocitos T (TCR) que comprende la región variable de la cadena alfa del TCR de la Fig 1a y la región variable de la cadena beta del TCR de la Fig 1b. The present invention provides TCRs having an affinity (K D ) of less than or equal to 1µM, and/or an off-rate (k off ) of 1x10 -3 S -1 or slower, for the SLYNTVATL-HLA-A*0201 complex PROVIDED THAT when the said TCR is presented by cell and comprises SEQ ID NOs: 1 and 2, the cell is not a native T cell. Such TCRs are useful, either alone or associated with a therapeutic agent, for targeting HIV infected cells presenting that complex.