Composiciones de poliuretano hidrófilo

• Main Authors: TUOMINEN, Jukka, HALLIDAY, Janet A, LIVINGSTON, Mark, ZURUTUZA, Amaia
• Format: Patent
• Language: Spanish
• Published: 22.03.2016
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

Una composición farmacéutica de liberación controlada en forma de dosificación sólida que comprende (i) un polímero lineal apto para hinchamiento en agua que se puede obtener haciendo reaccionar juntos (a) un óxido de polietileno de peso molecular medio menor o igual a 4000; (b) un diol C5 a C20 alifático; y (c) un isocianato difuncional, en el que la relación de los componentes (a) con respecto a (b) con respecto a (c) está dentro del intervalo 0,01-0,1 a 1 a 1,01-1,1 en términos de pesos equivalentes; junto con (ii) un agente farmacéuticamente activo. A water-swellable linear polymer is made by reacting together a polyethylene oxide of number average molecular weight less than 4000, an aliphatic diol and a difunctional isocyanate. Controlled release composition comprises the polymer together with an active agent. The polymer is able to take up pharmaceutically active agents of molecular weight 200 to 20,000.