Moléculas de unión a lectina de tipo C, identificación y usos de las mismas

• Main Authors: VAN KOOYK, Yvette, GEIJTENBEEK, Teunis
• Format: Patent
• Language: Spanish
• Published: 18.12.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Uso de un glicoconjugado que comprende un antígeno tumoral y un antígeno de Lewis x no sialilado capaz de unirse a DC-SIGN en una célula que presenta antígeno para la preparación de una composición para la estimulación de una respuesta inmune frente al antígeno tumoral en un individuo. C-type lectins are involved in the binding of many different types of carbohydrates. Considering their diversity in kind and expression of different types of cells, the influence of such binding is very diverse and dependent among others on the type of cell, the environment of the cell and the type of carbohydrate bound. In the present invention new carbohydrate specificities of C-type lectins are disclosed. Interference with this binding property has uses in the prevention of pathogen binding and also in influencing signaling pathways in the C-type lectin containing cell, particularly in Toll like receptor expressing cells such as dendritic cells. Also provided is the use of the carbohydrate specificity to enhance antigen presentation by antigen presenting cells and to manipulate migration of C-type lectin containing cells and the interaction of C-type lectin expressing cells with cellular ligands on neighboring cells.