Derivados de piperidinona como inhibidores de MDM2 para el tratamiento de cáncer

• Main Authors: WANG, XIAODONG, DUQUETTE, JASON, GRIBBLE, JR, DEIGNAN, JEFFREY, FISHER, BENJAMIN, MCGEE, LAWRENCE, EKSTEROWICZ, JOHN, MCINTOSH, JOEL, ZHU, JIANG, BECK, HILARY PLAKE, FU, JIASHENG, GUSTIN, DARIN JAMES, LI, ZHIHONG, JOHNSON, MICHAEL, MCMINN, DUSTIN, LAI, SUJEN, REW, YOSUP, HUANG, XIN, SUN, DAQING, WANG, YINGCAI, HEATH, JULIE ANNE, MEDINA, JULIO CESAR, BARTBERGER, MICHAEL DAVID, GONZALEZ LOPEZ DE TURISO, FELIX, LIU, JIWEN, CONNORS, RICHARD VICTOR, KOPECKY, DAVID JOHN, MA, ZHIHUA, FU, ZICE, MIHALIC, JEFFREY THOMAS, YAN, XUELEI, FOX, BRIAN MATTHEW, LOW, JONATHAN DANTE, CHEN, XIAOQI, JIAO, XIANYUN, KAYSER, FRANK, OLSON, STEVEN HOWARD, ROVETO, PHILIP MARLEY, GONZALEZ BUENROSTRO, ANA, LUCAS, BRIAN STUART, YU, MING, LI, YIHONG
• Format: Patent
• Language: Spanish
• Published: 15.07.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

El compuesto ácido 2-((3R,5R,6S)-5-(3-clorofenil)-6-(4-clorofenil)-1-((S)-1-(isopropilsulfonil)-3-metilbutan-2-il)-3 -metil-2-oxopiperidin-3-il)acético, o una sal farmacéuticamente aceptable del mismo. The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.