Derivados de piridina sustituidos heterocíclicos y agentes anti-fúngicos que los contienen

• Main Authors: MATSUKURA, MASAYUKI, TANAKA, KEIGO, MURAI, NORIO, INOUE, SATOSHI, SHIROTORI, SHUJI, NAKAMOTO, KAZUTAKA, ABE, SHINYA
• Format: Patent
• Language: Spanish
• Published: 03.11.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Un compuesto o una sal farmacéuticamente aceptable del mismo, seleccionándose el compuesto del grupo que consiste en 3-(3-(4-(piridin 5 -2-iloximetil)-bencil)-isoxazol-5-il)-piridin-2-ilamina; 3-(3-(4-(piridin-2-ilmetoxi)-bencil)-isoxazol-5-il)-piridin-2-ilamina; 3-(3-(4-(piridin-2-iloximetil)-bencil)-isoxazol-5-il)-piridina-2,6-diamina; 3-(3-(6-benciloxi-piridin-3-ilmetil)-isoxazol-5-il)-piridin-2,6-diamina; y 3-(1-(4-(piridin-2-iloximetil)-bencil)-1H-pìrazol-4-il)-piridina-2-ilamina. An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound or a pharmaceutically acceptable salt thereof, the compound being selected from the group consisting of 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine; 3-(3-(4-(Pyridin-2-ylmethoxy)-benzyl)-isoxazol-5-yl)-pyridin-2-ylamine; 3-(3-(4-pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridine-2,6-diamine; 3-(3-(6-benzyloxy-pyridin-3-ylmethyl)-isoxazol-5-yl)-pyridin-2,6-diamine; and 3-(1-(4-(pyridin-2-yloxymethyl)-benzyl)-1H-pyrazol-4-yl)-pyridin-2-ylamine.