Composiciones que comprenden (S)-2-amino-1-(4-clorofenil)-1-[4-(1H-pirazol-4-il)-fenil]-etanol como moduladores de proteínas quinasas

• Main Authors: REES, DAVID CHARLES, WOODHEAD, STEVEN JOHN, GRIMSHAW, KYLA MERRIOM, FREDERICKSON, MARTYN
• Format: Patent
• Language: Spanish
• Published: 23.10.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Una composición que comprende 2-amino-1-(4-cloro- fenil)-1-[4-(1H-pirazol-4-il)-fenil]-etanol o una sal, solvato, tautómero o N-óxido del mismo, al menos un 90% del cual está en la forma enantiomérica S. The invention provides a composition comprising ( S ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of ( R ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the ( S ) and ( R ) enantiomers in which the ( S ) enantiomer predominates. Also provided are processes for the preparation of the ( S ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.