Derivados de bifenilamida-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1

• Main Authors: AICHER, THOMAS, CHEN, ZHAOGEN, YORK, JEREMY, MCCOWAN, JEFFERSON, KRASUTSKY, ALEXEI, SNYDER, NANCY, HINKLIN, RONALD, XU, YANPING, HITE, GARY, SAEED, ASHRAF, LI, RENHUA, WALLACE, OWEN, TOTH, JAMES, WINNEROSKI, JUNIOR
• Format: Patent
• Language: Spanish
• Published: 18.12.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

compuesto estructuralmente representado por la fórmula:**Fórmula** en la que: R1 es**Fórmula** en los que la línea de trazos representa el punto de unión a la posición R1 en la fórmula I; R2 es -H, -halógeno, -CH3 (opcionalmente sustituido con 1 a 3 halógenos), o -O-CH3 (opcionalmente sustituidocon 1 a 3 halógenos); R3 es -halógeno, -CH3 (opcionalmente sustituido con 1 a 3 halógenos), o -O-CH3 (opcionalmente sustituido con 1a 3 halógenos); R4 es -H o -halógeno; R5 es**Fórmula** The present invention discloses novel compounds of Formula I: possessing 11 -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 -HSD type 1 activity.