Derivados de amida sustituida como inhibidores de proteína cinasa

• Main Authors: CHOQUETTE, DEBORAH, BELLON, STEVEN, D'AMICO, DERIN, LEE, MATTHEW, HARMANGE, JEAN-CRISTOPHE, ROVETO, PHILIP, GERMAIN, JULIE, BAUER, DAVID, FELLOWS, INGRID M, LA, DANIEL, NORMAL, MARK H, XI, NING, YANG, KEVIN, KIM, TAE-SEONG, POTHASHMAN, MICHELE, GRACEFFA, RUSSEL, D'ANGELO, NOEL, SIEGMUND, AARON C, BOOKER, SHON, DOMINGUEZ, CELIA, HIRAI, SATOKO, LIU, LONGBIN, BOEZIO, ALESSANDRO
• Format: Patent
• Language: Spanish
• Published: 20.02.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compuesto de fórmula I R-X-W-Y-R1 I enantiómeros, diastereómeros, sales farmacológicamente aceptables y N-óxidos del mismo, en el que R es en el que Z se selecciona de N o CR7; Z1 se selecciona de N o CR7; W se selecciona de fenilo sustituido o no sustituido, piridilo sustituido o no sustituido, pirimidinilo sustituido o no sustituido, piridazinilo sustituido o no sustituido y pirazinilo sustituido o no sustituido; X es O; Y se selecciona de -NRaC(>=O)-(CR3R4)p- y -NRaC(>=S)-(CR3R4)p-; Ra se selecciona de H, alquilo, heterociclilo, arilo, alquenilo y alquinilo; R1 se selecciona de: **Fórmula** Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.