Procedimiento de preparación de un antagonista de leucotrienos y de un intermedio del mismo

Compuesto de fórmula IIa,o un solvato farmacéuticamente aceptable del mismo. Dicyclohexylamine salt of formula (IIa) or a pharmaceutically acceptable solvate thereof, including a hydrate, and its process for preparation are provided. The invention also relates to processes for the preparation of mon...

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Bibliographic Details
Main Authors CAMPS RAMIREZ DE CARTAGENA, HELENA, SANCHEZ CASALS, CARLES
Format Patent
LanguageSpanish
Published 12.02.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compuesto de fórmula IIa,o un solvato farmacéuticamente aceptable del mismo. Dicyclohexylamine salt of formula (IIa) or a pharmaceutically acceptable solvate thereof, including a hydrate, and its process for preparation are provided. The invention also relates to processes for the preparation of montelukast of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, including a hydrate, based on the conversion of a salt of formula (IIa) into its form of free acid, followed by reaction with a compound of formula (III) CH3MgX, wherein X is halogen, in a suitable solvent, optionally in the presence of a Lewis acid.
Bibliography:Application Number: ES20080786600T