Derivatives of prenyled dibenzofuranic polygenes and their application for the treatment of infectious, parasitic diseases and tumors. (Machine-translation by Google Translate, not legally binding)

• Main Authors: MACHIN CONCEPCION, FELIX MANUEL, MENDEZ ALVAREZ, SEBASTIAN, ESTEVEZ BRAUM, ANA MARIA, DEMO, MIRTA SUSANA, CASERO, CARINA NOELIA, GUTIERREZ RAVELO, ANGEL DOMINGO
• Format: Patent
• Language: English; Spanish
• Published: 23.10.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Antimicrobial, antitumor and antiparasitic activity of prenylated dibenzofuranic polyketide derivatives. The present invention describes a family of compounds that are prenylated dibenzofuran polyketides of natural origin that possess an antimicrobial activity, particularly against gram positive bacteria. These compounds also have cytotoxic activity against various tumor cell lines, as well as antiparasitic activity, so they are useful for the manufacture of antitumor drugs and for the treatment of infectious diseases of bacterial and parasitic origin. (Machine-translation by Google Translate, not legally binding) Actividad antimicrobiana, antitumoral y antiparasitaria de derivados de policétidos dibenzofuránicos prenilados.La presente invención describe una familia de compuestos que son policétidos dibenzofuránicos prenilados de origen natural que poseen una actividad antimicrobiana, particularmente contra bacterias gram positivas. Asimismo estos compuestos presentan actividad citotóxica frente a diversas líneas celulares tumorales, así como actividad antiparasitaria, por lo que son útiles para la fabricación de medicamentos antitumorales y para el tratamiento de enfermedades infecciosas de origen bacteriano y parasitario.